• Sakshi Prasad, Abdulrahim Mehadi, Nirja Kaka, Sharan Jhaveri, Chaithanya Avanthika, Neil Patel, Ivan Augustine, and Ali Issani.
• Faculty of Medicine National Pirogov Memorial Medical University, 21018, Vinnytsya, Ukraine. Electronic address: sakshiprasad8@gmail.com.
• Dis Mon. 2022 Aug 1; 68 (8): 101316.

AbstractCluster Headaches are one of the most arguably severe forms of primary headache syndrome that affects humans. Although it is relatively uncommon, it has a significant impact on the quality of life. It is a multifactorial disease that has risk factors ranging from seasonal changes, lifestyle habits to genetics. It occurs in 2 forms- Episodic and Chronic, each having its well-defined Diagnostic Criteria. Moreover, Cluster Headache has an exhaustive list of options for both Preventive and Abortive treatment. This article focuses on Cluster Headache, its pathophysiology, risk factors, differentials, and its diverse treatment modalities. In this study, an all-language literature search was conducted on Medline, Cochrane, Embase, and Google Scholar till October 2021. The following search strings and Medical Subject Headings (MeSH) terms were used: "Cluster Headache," "Triptans," "Neuromodulation," and "Migraine." We explored the literature on Cluster Headache for its epidemiology, pathophysiology, the role of various genes and how they bring about the disease as well as its episodic and chronic variants, and treatment options. Although we have a wide variety of options for Preventive and Abortive therapy, newer more effective pharmacological and non-pharmacological interventions are being developed, and must be integrated into new treatment protocols.Copyright © 2021. Published by Elsevier Inc.

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