• C James Watson, Genevra L Stone, Daniel L Overbeek, Takuyo Chiba, and Michele M Burns.
• Harvard Medical Toxicology Program, Boston Children's Hospital, Boston, MA, USA.
• J. Intern. Med. 2022 Feb 1; 291 (2): 181-196.

AbstractThe rules of fair play in sport generally prohibit the use of performance-enhancing drugs (PEDs). The World Anti-Doping Agency (WADA) oversees global antidoping regulations and testing for elite athletes participating in Olympic sports. Efforts to enforce antidoping policies are complicated by the diverse and evolving compounds and strategies employed by athletes to gain a competitive edge. Now between the uniquely proximate 2021 Tokyo and 2022 Beijing Olympic Games, we discuss WADA's efforts to prevent PED use during the modern Olympic Games. Then, we review the major PED classes with a focus on pathophysiology, complexities of antidoping testing, and relevant toxicities. Providers from diverse practice environments are likely to care for patients using PEDs for a variety of reasons and levels of sport; these providers should be aware of common PED classes and their risks.© 2021 The Association for the Publication of the Journal of Internal Medicine.

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