• Micaela A Gritti, Marília Melo Favalesso, Leyla G Gómez Capará, and María Elisa Peichoto.
• Hospital Escuela Gral. José Francisco de San Martín, Corrientes, Argentina.
• Medicina (B Aires). 2021 Jan 1; 81 (6): 946-953.

AbstractCarbapenemaseproducing bacteria are involved in infections and colonizations and associated with high morbidity and mortality. Their identification facilitates the design and implementation of interventions aimed at reducing the risk of infections and deaths. The objective of this study was to determine the prevalence of carbapenemase-producing microorganisms in the main public hospital in the city of Corrientes, Argentina, and to determine their susceptibility to antibiotics commonly used in clinical practice. We analyzed 674 clinical samples from the same number of adults admitted to different inpatient units of the Hospital Escuela Gral. José Francisco de San Martín during the period September-December 2018. The bacterial identification was carried out through manual biochemical tests and the susceptibility to antimicrobials was evaluated according to the recommendations of the Clinical and Laboratory Standards Institute. We identified 115 carbapenemase-producing bacteria of the following types: KPC (90, 78%), OXA-ACI (24, 21%) and OXA-163 (≈1%). Among the microorganisms involved in infections (n = 56; 49%), most of those of the KPC type (n = 32; 57%) showed sensitivity only against amikacin (27/32; 84%), while most of those of the OXA-ACI type ( 24; 43%) showed significant sensitivity only against minocycline (17/24; 71%) and colistin (n = 19/24; 79%). This study demonstrated the presence of carbapenemase-producing microorganisms in all the investigated hospital units and a high frequency of resistance to antimicrobials commonly used in clinical practice. This information is relevant to adapt the therapeutic schemes and hygienic-sanitary measures to the local reality.

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