• Neuroreport · Nov 2007

    Neuromuscular block and the electroencephalogram during sevoflurane anaesthesia.

    • Andreas Ekman, Roland Flink, Eva Sundman, Lars I Eriksson, Lars Brudin, and Rolf Sandin.
    • Department of Physiology and Pharmacology, Section for Anaesthesiology and Intensive Care Medicine, Karolinska Institutet, Stockholm, Sweden. andrease@ltkalmar.se
    • Neuroreport. 2007 Nov 19;18(17):1817-20.

    AbstractThe effect of neuromuscular block on the anaesthetic depth of hypnosis is an elusive question. We simultaneously investigated the influence of neuromuscular block on the bispectral index, a measure of hypnosis during general anaesthesia, and on the electroencephalogram. Patients were anaesthetized with sevoflurane. Noxious tetanic electrical stimulation was applied on two occasions: before and after profound neuromuscular block achieved with rocuronium. Neuromuscular block significantly attenuated the effect from noxious stimulation on electroencephalogram power and synchrony in the gamma band (P<0.05), and the corresponding effect on bispectral index (P<0.02). These findings are probably due to the reduced arousing afferent input from paralysed muscles, and not to changes in the frontal electromyogram.

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