• Internal medicine · Sep 2022

    Case Reports

    Secondary Skin Cancer in a Case with Long-term Voriconazole after Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia.

    • Noriaki Kawano, Shunou Nakamura, Kousuke Mochida, Shuro Yoshida, Takuro Kuriyama, Takashi Nakaike, Tomonori Shimokawa, Taro Tochigi, Kiyoshi Yamashita, Koichi Mashiba, Ikuo Kikuchi, Aina Takarabe, Sayaka Moriguchi, Yasuo Mori, Katsuto Takenaka, Kazuya Shimoda, Hidenobu Ochiai, and Masahiro Amano.
    • Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Japan.
    • Intern. Med. 2022 Sep 15; 61 (18): 2771-2774.

    AbstractSecondary malignancies that develop after allogeneic-hematopoietic stem cell transplantation (allo-HSCT) have become serious issues. A 47-year-old man who developed acute myeloid leukemia in 2009 and subsequently underwent allo-HSCT twice: in 2009 and 2011. In 2015, voriconazole for lung aspergillus was started. In 2018, chronic graft-versus-host disease (GVHD) and multiple actinic keratoses manifested at his head. In 2020, some lesions were diagnosed as squamous cell carcinoma, so voriconazole was withdrawn, and subsequent surgery and radiation led to remission. Long-term administration of voriconazole in addition to allo-HSCT and chronic GVHD may be closely related to secondary skin cancer.

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