• Internal medicine · Jan 2022

    Case Reports

    Carney Complex Complicated with Primary Pigmented Nodular Adrenocortical Disease without Cushing's Syndrome Recurrence for Five Years after Unilateral Adrenalectomy.

    • Yuya Tsurutani, Kanako Kiriyama, Mai Kondo, Masanori Hasebe, Akira Sata, Yuzo Mizuno, Chiho Sugisawa, Jun Saito, and Tetsuo Nishikawa.
    • Endocrinology and Diabetes Center, Yokohama Rosai Hospital, Japan.
    • Intern. Med. 2022 Jan 1; 61 (2): 205-211.

    AbstractWe herein report a case of Carney complex (CNC) complicated with primary pigmented nodular adrenocortical disease (PPNAD) after unilateral adrenalectomy. A 44-year-old woman was admitted to our hospital for PPNAD surgery. She had previously undergone surgery for cardiac myxoma and had a PRKAR1A mutation with no family history of CNC. She had Cushing's signs, but her metabolic abnormalities were mild. Adrenal insufficiency due to poor medication adherence was a concern, so she underwent unilateral adrenalectomy. Cushing's signs improved postoperatively and without recurrence for five years. Treatment plans for PPNAD should be determined based on the patient's condition, medication adherence, and wishes.

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