• Am. J. Med. Sci. · Jan 2022

    Review Case Reports

    Disseminated Cryptococcosis in An Immunocompetent Host Presenting As Osteomyelitis and Leading to Adrenal Insufficiency.

    • Emory Hsu, Sara Markley Webster, and Mark Nanes.
    • Division of Endocrinology, Santa Clara Valley Medical Center, San Jose, CA, United States; Department of Medicine, Stanford University School of Medicine, Palo Alto, CA, United States. Electronic address: emory.hsu@hhs.sccgov.org.
    • Am. J. Med. Sci. 2022 Jan 1; 363 (1): 75-79.

    AbstractDisseminated cryptococcosis infection typically occurs in immunocompromised patients, often through pneumonia or meningoencephalitis. Cases in immunocompetent patients are uncommon, and presentation in either bone or adrenal glands are rare. We describe a case of a previously healthy immunocompetent 50-year-old woman who presented with lytic bone lesions followed by meningoencephalitis, dermatologic involvement, and adrenal insufficiency from disseminated cryptococcus. To our knowledge, this is the first case report of an immunocompetent patient with cryptococcus in the combination of blood, bone, skin, central nervous system, and adrenal glands. Clinicians should be aware of atypical presentations of cryptococcal disease. In this review of the literature on cryptococcosis in immunocompetent patients, we find that while rare, cryptococcosis can affect varied organs and should be considered in the differential of infectious diseases.Copyright © 2020 Southern Society for Clinical Investigation. All rights reserved.

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