• Yanru Cui, Jilin Wang, Gaofeng Wang, Xiuguo Xie, and Lizhen Tian.
• First College of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
• Medicine (Baltimore). 2021 Dec 3; 100 (48): e27933e27933.

BackgroundThe COVID-19 (coronavirus disease 2019) pandemic continues to have an immense impact on the world at large. COVID-19 patients who meet the discharge criteria, may subsequently exhibit positive viral RNA test results upon subsequent evaluation. This phenomenon has been a major source of research and public health interest, and poses a major challenge to COVID-19 prevention, treatment, and standardized patient management.MethodsWe will search the PubMed, MEDLINE, Embase, Cochrane Clinical Trials Database, China National Knowledge Infrastructure, Wanfang Database, Chinese Science Journal Database, and China Biology Medicine databases for all studies published as of November 2021. Data will be extracted independently by two researchers according to the eligibility criteria. Finally, RevMan 5.3.0 will be implemented for statistical analyses.ResultsThe results of this study will show the prevalence and risk factors associated with repeat positive SARS-CoV-2 nucleic acid test results among discharged COVID-19 patients.ConclusionsThis study will provide a reliable evidence-based for the prevalence and risk factors associated with repeat positive SARS-CoV-2 nucleic acid test results among discharged COVID-19 patients.Trial Registration NumberCRD42021272447.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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