• Xuefeng Li, Heran Wang, Xue Zhou, Dongyang Ma, Jiapeng Chai, Jiayi Liu, Xin Qian, Chunhai Chen, and Xinhua Chen.
• Department of Acupuncture and Tuina, Changchun University of Chinese Medicine, Changchun, China.
• Medicine (Baltimore). 2021 Dec 3; 100 (48): e28042.

BackgroundDiabetic peripheral neuropathy (DPN) is one of the most common microvascular complications of diabetes mellitus, with an incidence ranging from 60% to 90%. With the change in modern dietary structure, the incidence of diabetes is increasing year by year, and DPN is also on the rise. Acupuncture and Tuina treatments are often combined to treat DPN; however, there has been no meta-analysis on their synergistic effect; therefore, we aimed to perform a systematic review and meta-analysis to estimate the effectiveness of acupuncture combined with Tuina in DPN treatment.MethodsNine electronic databases were retrieved for this study. The English databases mainly retrieved PubMed, Web of Science, Embase, AMED, and the Cochrane Library, while the CNKI, VIP, CBM, and Wanfang databases were used to retrieve the Chinese literature; there was no definite time limit for the retrieval literature, and the languages were limited to Chinese and English. We will consider articles published between database initiation and November 2021. We used Review Manager 5.4 software provided by the Cochrane Collaborative Network for statistical analysis. We then assessed the quality and risk of the included studies and observed the outcome measures.ResultsThis study provides a high-quality synthesis to assess the effectiveness and safety of acupuncture combined with Tuina for treating DPN.ConclusionThis systematic review provided evidence to determine whether acupuncture combined with Tuina is an effective and safe intervention for patients with DPN.Ethics And DisseminationThe protocol for this systematic review does not require ethical approval because it does not involve humans. This article will be published in peer-reviewed journals and presented at relevant conferences.Systematic Review RegistrationINPLASY2021110017.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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