• Gajin Han, Seok-Jae Ko, Keumji Kim, Hyejin Jun, and Jae-Woo Park.
• Kyung Hee Sweet & Sunny Korean Medicine Clinic, Gyeonggi-do, Republic of Korea.
• Medicine (Baltimore). 2021 Dec 3; 100 (48): e28116.

BackgroundIrritable bowel syndrome (IBS) is a functional bowel disorder with symptoms of recurrent abdominal pain associated with a change in stool frequency or appearance that decreases patient quality of life. Conventional Western medicine has limited efficacy in treating IBS. Tongsayobang (TSYB) is a traditional Korean medicine that has been used to treat lower intestinal problems. This study provides a procedure for conducting a systematic review of the efficacy and safety of TSYB for IBS.Methods And AnalysisThe main electronic databases will be searched up to May 2021 for randomized controlled trials and quasi-randomized controlled trials evaluating the effect of TSYB or modified TSYB on patients with IBS. The primary outcome will be the overall efficacy rate. The secondary outcome will be data such as IBS-related quality of life, global symptom scores, and adverse events. This study will adopt the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement, and will involve a meta-analysis, if possible. The methodological quality of the included studies will be assessed using the Risk of Bias tool from the Cochrane Handbook, version 6.1.0.Ethics And DisseminationEthical approval is not required because this study does not include any participants' personal information.Osf Registration NumberDOI 10.17605/OSF.IO/M32BK (https://osf.io/m32bk).Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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