• J. Intern. Med. · Jun 2022

    Post-Covid-19-vaccination adverse events and healthcare utilization among individuals with or without previous SARS-CoV-2 infection.

    • Francisco Tsz Tsun Lai, Lei Huang, Kuan Peng, Xue Li, Celine Sze Ling Chui, Eric Yuk Fai Wan, WongCarlos King HoCKH0000-0002-6895-6071Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.Laboratory of Data Discovery for Health (, ChanEsther Wai YinEWYCentre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.Laboratory of Data Discovery for Health (D24H), Hong Kong Sc, Ivan Fan Ngai Hung, and WongIan Chi KeiICKCentre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.Laboratory of Data Discovery for Health (D24H), Hong Kong Scien.
    • Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
    • J. Intern. Med. 2022 Jun 1; 291 (6): 864-869.

    BackgroundPost-marketing pharmacovigilance data are scant on the safety of Covid-19 vaccines among people with previous SARS-CoV-2 infection compared with ordinary vaccine recipients. We compared the post-vaccination adverse events of special interests (AESI), accident and emergency room (A&E) visit, and hospitalization between these two groups.MethodsWe conducted a retrospective cohort study using a territory-wide public healthcare database with population-based vaccination records in Hong Kong.ResultsIn total, 3922 vaccine recipients with previous SARS-CoV-2 infection and 1,137,583 vaccine recipients without previous SARS-CoV-2 infection were included. No significant association was observed between previous SARS-CoV-2 infection and AESI or hospitalization. Previous SARS-CoV-2 infection was significantly associated with a lower risk of A&E visit (CoronaVac: hazard ratios [HR] = 0.56, 95% confidence intervals [CI]: 0.32-0.99; Comirnaty: HR = 0.62, 95% CI: 0.47-0.82).ConclusionNo safety signal of Covid-19 vaccination was detected from the comparison between vaccine recipients with previous SARS-CoV-2 infection and those without infection.© 2022 The Authors. Journal of Internal Medicine published by John Wiley & Sons Ltd on behalf of Association for Publication of The Journal of Internal Medicine.

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