• MeskersCarel G MCGMDepartment of Rehabilitation Medicine, Amsterdam University Medical Centers, Amsterdam Movement Sciences, Amsterdam, The Netherlands., Sabina van der Veen, Jenia Kim, Caroline J W Meskers, Quirine T S Smit, Stella Verkijk, Edwin Geleijn, WiddershovenGuy A MGAMDepartment of Ethics, Law and Humanities, Amsterdam University Medical Centers, Amsterdam, The Netherlands., Piek T J M Vossen, and Marike van der Leeden.
• Department of Rehabilitation Medicine, Amsterdam University Medical Centers, Amsterdam Movement Sciences, Amsterdam, The Netherlands.
• Ann. Med. 2022 Dec 1; 54 (1): 235243235-243.

PurposeTo address the feasibility, reliability and internal validity of natural language processing (NLP) for automated functional assessment of hospitalised COVID-19 patients in key International Classification of Functioning, Disability and Health (ICF) categories and levels from unstructured text in electronic health records (EHR) from a large teaching hospital.Materials And MethodsEight human annotators assigned four ICF categories to relevant sentences: Emotional functions, Exercise tolerance, Walking and Moving, Work and Employment and their ICF levels (Functional Ambulation Categories for Walking and Moving, metabolic equivalents for Exercise tolerance). A linguistic neural network-based model was trained on 80% of the annotated sentences; inter-annotator agreement (IAA, Cohen's kappa), a weighted score of precision and recall (F1) and RMSE for level detection were assessed for the remaining 20%.ResultsIn total 4112 sentences of non-COVID-19 and 1061 of COVID-19 patients were annotated. Average IAA was 0.81; F1 scores were 0.7 for Walking and Moving and Emotional functions; RMSE for Walking and Moving (5- level scale) was 1.17 for COVID-19 patients.ConclusionUsing a limited amount of annotated EHR sentences, a proof-of-concept was obtained for automated functional assessment of COVID-19 patients in ICF categories and levels. This allows for instantaneous assessment of the functional consequences of new diseases like COVID-19 for large numbers of patients.Key messagesHospitalised Covid-19 survivors may persistently suffer from low physical and mental functioning and a reduction in overall quality of life requiring appropriate and personalised rehabilitation strategies.For this, assessment of functioning within multiple domains and categories of the International Classification of Function is required, which is cumbersome using structured data.We show a proof-of-concept using Natural Language Processing techniques to automatically derive the aforementioned information from free-text notes within the Electronic Health Record of a large academic teaching hospital.

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