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- Lonneke M L de Lau and Monique M B Breteler.
- Department of Epidemiology & Biostatistics, Erasmus Medical Centre Rotterdam, Netherlands.
- Lancet Neurol. 2006 Jun 1; 5 (6): 525-35.
AbstractThe causes of Parkinson's disease (PD), the second most common neurodegenerative disorder, are still largely unknown. Current thinking is that major gene mutations cause only a small proportion of all cases and that in most cases, non-genetic factors play a part, probably in interaction with susceptibility genes. Numerous epidemiological studies have been done to identify such non-genetic risk factors, but most were small and methodologically limited. Larger, well-designed prospective cohort studies have only recently reached a stage at which they have enough incident patients and person-years of follow-up to investigate possible risk factors and their interactions. In this article, we review what is known about the prevalence, incidence, risk factors, and prognosis of PD from epidemiological studies.
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