• Vet Hum Toxicol · Apr 2000

    Case Reports

    The futility of hemoperfusion and hemodialysis in Amanita phalloides poisoning.

    • M E Mullins and B Z Horowitz.
    • Oregon Poison Center, Portland, USA.
    • Vet Hum Toxicol. 2000 Apr 1;42(2):90-1.

    AbstractAmanita phalloides mushrooms are extremely toxic. A variety of treatments have been proposed based as often on anecdotal experience as on firm evidence. General consensus exists regarding some treatments, such as the use of silibinin, penicillin, and activated charcoal. The most polarized debate concerns the value of extracorporeal elimination. We describe a case of 2 adults with confirmed Amanita phalloides poisoning treated with hemodialysis (HD) immediately after arrival at our tertiary care hospital (23 h after ingestion) and later with hemoperfusion (HP); a series blood samples were taken to determine the clearance of the toxin by each method. No amatoxin was detected before treatment, after treatment, or in the HD/HP circuits. Neither HD nor HP contributed to the clearance of amatoxin.

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