• Shanshan Wu, Yinyin Xia, Xiaozhen Lv, Yuan Zhang, Shaowen Tang, Zhirong Yang, Dehua Tu, Peiyuan Deng, Shiming Cheng, Xiaomeng Wang, Yanli Yuan, Feiying Liu, Daiyu Hu, and Siyan Zhan.
• Department of Epidemiology and Bio-statistics, School of Public Health, Peking University Health Science Centre, Haidian District, Beijing 100191, China.
• Bmc Public Health. 2012 Jan 1;12:454.

BackgroundData on effect of regular liver function monitoring during anti-TB treatment is limited in China. This study aimed to evaluate the effects of scheduled liver function monitoring on identification of asymptomatic liver damage and anti-TB treatment outcomes during anti-TB treatment.MethodsA retrospective analysis was performed based on a national-level cohort study. A total of 273 patients developing liver dysfunction were divided into two groups, 111 patients who were diagnosed through scheduled liver function test within two months after initiation of anti-TB treatment formed scheduled monitoring group, others who were diagnosed due to developing symptoms formed passive detection group (n = 162). The two groups were compared through clinical features, prognosis of liver dysfunction and impact on anti-TB treatment using propensity score weighting analysis.Results33.3% of 273 patients did not have any clinical symptoms, including 8 with severe hepatotoxicity. 1.8% in scheduled monitoring group and 11.1% in passive detection group required hospitalization (P = 0.004). Regarding the prognosis of liver dysfunction, most patients recovered, no death happened in scheduled monitoring group while 3 died in passive detection group. In terms of impact on anti-TB treatment, 35.1% in scheduled monitoring group and 56.8% in passive detection group changed their anti-TB treatment (P = 0.001).ConclusionsScheduled monitoring is effective in identifying asymptomatic liver damage, reducing hospitalization rate and improving compliance of anti-TB treatment.

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