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- Yasunobu Sekiguchi, You Nishimura, Hiroaki Kanda, Machiko Kawamura, Kazuhiko Kobayashi, and Hirofumi Kobayashi.
- Department of Hematology, Saitama Cancer Center, Japan.
- Intern. Med. 2022 Aug 15; 61 (16): 2503-2508.
AbstractA 74-year-old woman was diagnosed with Waldenstrom macroglobulinemia/lymphoplasmacytic lymphoma (WM/LPL) in X-18. Fludarabine plus rituximab (FR) was started, and she showed remission. In July X-7, the serum creatinine (Cr) level increased to 1.67 mg/dL, and bendamustine plus rituximab (BR) was started. By November X-7, the Cr level had increased to 8.41 mg/dL, so she was started on hemodialysis (HD). In September X-1, she developed nephrotic syndrome. She was started on tirabrutinib at 480 mg. In July X, her nephrotic syndrome had improved, and a complete response (CR) was achieved. This is the first case of the administration of tirabrutinib in a patient undergoing HD.
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