• Internal medicine · Aug 2022

    Case Reports

    Resection of Gastric Cancer Remitted Anti-signal Recognition Particle Myopathy.

    • Yoshihide Sehara, Kyoichiro Tsuchiya, Ichizo Nishino, Hirotake Sato, and Yoshihito Ando.
    • Department of Neurology, Haga Red Cross Hospital, Japan.
    • Intern. Med. 2022 Aug 15; 61 (16): 2509-2515.

    AbstractA 72-year-old woman presented with gradually-worsening myalgia and muscle weakness of the proximal lower limbs as well as elevated serum creatine kinase level. Based on a clinicoseropathological examination including a muscle biopsy, she was diagnosed with anti-signal recognition particle (SRP) myopathy. Although the myopathy relapsed two times in two years under oral prednisolone and intravenous immunoglobulin therapy, the myopathy remained in remission for more than three years after resection of gastric cancer. Although the anti-SRP myopathy is not considered to be cancer-associated in general, we should note that some cases of anti-SRP myopathy may be ameliorated with appropriate cancer treatment.

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