• Int. J. Clin. Pract. · Dec 2007

    Review

    New agents in development for the management of obesity.

    • R P Vincent and C W le Roux.
    • Department of Chemical Pathology, King's College Hospital, London, UK.
    • Int. J. Clin. Pract. 2007 Dec 1; 61 (12): 2103-12.

    AbstractObesity is fast becoming the major cause of premature death in the developed world. The rising prevalence of obesity and obesity-related comorbidities also elevates healthcare costs, and reduced quality of life. The National Institute of Clinical Excellence in the UK recommends pharmacotherapy, in conjunction with lifestyle modification, for obese individuals [i.e. body mass index (BMI) of 30 kg/m(2)] and for overweight persons with a BMI greater than 27 kg/m(2), accompanied by at least one comorbidity. However, the current pharmaceutical treatment available to combat this epidemic remains limited. We review the efficacy and pharmacology of the anti-obesity agents currently used in clinical practice as well as some of the potential agents in phase II and III trials.

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