• Medicine · May 2015

    Impact of bariatric surgery on carotid artery inflammation and the metabolic activity in different adipose tissues.

    • Jan Bucerius, Guy H E J Vijgen, Boudewijn Brans, Nicole D Bouvy, Matthias Bauwens, RuddJames H FJHF, Bas Havekes, Zahi A Fayad, Wouter D van Marken Lichtenbelt, and Felix M Mottaghy.
    • From the Department of Nuclear Medicine (JB, BB, MB, FMM); Cardiovascular Research Institute Maastricht (CARIM) (JB), Maastricht University Medical Center, Maastricht, The Netherlands; Department of Nuclear Medicine (JB, FMM), University Hospital, RWTH Aachen, Aachen, Germany; Department of Human Biology (GHEJV, MB, BH, WDVML), School for Nutrition, Toxicology, and Metabolism (NUTRIM); Department of General Surgery (GHEJV, NDB), Maastricht University Medical Center, Maastricht, The Netherlands; Division of Cardiovascular Medicine (JHFR), University of Cambridge, Cambridge, UK; Division of Endocrinology (BH), Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands; Translational and Molecular Imaging Institute (ZAF); Department of Radiology (ZAF); and Department of Cardiology, Zena and Michael A. Weiner Cardiovascular Institute, and Marie-Josée and Henry R. Kravis Cardiovascular Health Center (ZAF), Icahn School of Medicine at Mount Sinai, New York, USA.
    • Medicine (Baltimore). 2015 May 1; 94 (20): e725.

    AbstractIn this study, we unravel a molecular imaging marker correlated with the known reduction of cardiovascular events (most commonly related to vulnerable plaques) in morbidly obese patients after bariatric surgery (BaS).We prospectively imaged 10 morbidly obese subjects with F-fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography before and 1 year after BaS. F-FDG uptake-which is enhanced in inflamed, atherosclerotic vessels and in metabolically active adipose tissues-was quantified in the carotids, pericardial adipose tissue (PAT), visceral adipose tissue (VAT), as well as brown adipose tissue (BAT). The degree of carotid inflammation was compared to lean and overweight controls.Carotid inflammation significantly declined leading to an F-FDG uptake comparable to the 2 control groups. Metabolic activity significantly decreased in PAT and VAT and increased in BAT.BaS leads to a normalization of carotid artery inflammation and a beneficial impact on the metabolic activity in PAT, VAT, and BAT that is related to the metabolic syndrome observed in this patient group.

      Pubmed     Free full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…