• Kaspar Staub, Radoslaw Panczak, Katarina L Matthes, Joël Floris, Claudia Berlin, Christoph Junker, Rolf Weitkunat, Svenn-Erik Mamelund, Marcel Zwahlen, and Julien Riou.
• Institute of Evolutionary Medicine, University of Zurich, Zurich, Switzerland (K.S., K.L.M.).
• Ann. Intern. Med. 2022 Apr 1; 175 (4): 523532523-532.

BackgroundExcess mortality quantifies the overall mortality impact of a pandemic. Mortality data have been accessible for many countries in recent decades, but few continuous data have been available for longer periods.ObjectiveTo assess the historical dimension of the COVID-19 pandemic in 2020 for 3 countries with reliable death count data over an uninterrupted span of more than 100 years.DesignObservational study.SettingSwitzerland, Sweden, and Spain, which were militarily neutral and not involved in combat during either world war and have not been affected by significant changes in their territory since the end of the 19th century.ParticipantsComplete populations of these 3 countries.MeasurementsContinuous series of recorded deaths (from all causes) by month from the earliest available year (1877 for Switzerland, 1851 for Sweden, and 1908 for Spain) were jointly modeled with annual age group-specific death and total population counts using negative binomial and multinomial models, which accounted for temporal trends and seasonal variability of prepandemic years. The aim was to estimate the expected number of deaths in a pandemic year for a nonpandemic scenario and the difference in observed and expected deaths aggregated over the year.ResultsIn 2020, the number of excess deaths recorded per 100 000 persons was 100 (95% credible interval [CrI], 60 to 135) for Switzerland, 75 (CrI, 40 to 105) for Sweden, and 155 (CrI, 110 to 195) for Spain. In 1918, excess mortality was 6 to 7 times higher. In all 3 countries, the peaks of monthly excess mortality in 2020 were greater than most monthly excess mortality since 1918, including many peaks due to seasonal influenza and heat waves during that period.LimitationHistorical vital statistics might be affected by minor completeness issues before the beginning of the 20th century.ConclusionIn 2020, the COVID-19 pandemic led to the second-largest infection-related mortality disaster in Switzerland, Sweden, and Spain since the beginning of the 20th century.Primary Funding SourceFoundation for Research in Science and the Humanities at the University of Zurich, Swiss National Science Foundation, and National Institute of Allergy and Infectious Diseases.

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