• N. Engl. J. Med. · Feb 2022

    Mosquito Net Use in Early Childhood and Survival to Adulthood in Tanzania.

    • Günther Fink, Sigilbert Mrema, Salim Abdulla, S Patrick Kachur, Rashid Khatib, Christian Lengeler, Honorati Masanja, Fredros Okumu, and Joanna Schellenberg.
    • From the Swiss Tropical and Public Health Institute and the University of Basel, Basel, Switzerland (G.F., C.L.); Ifakara Health Institute, Dar es Salaam, Tanzania (S.M., S.A., R.K., H.M., F.O.); Mailman School of Public Health, Columbia University, New York (S.P.K.); and the London School of Hygiene and Tropical Medicine, London (J.S.).
    • N. Engl. J. Med. 2022 Feb 3; 386 (5): 428-436.

    BackgroundIt has been hypothesized that in high-transmission settings, malaria control in early childhood (<5 years of age) might delay the acquisition of functional immunity and shift child deaths from younger to older ages.MethodsWe used data from a 22-year prospective cohort study in rural southern Tanzania to estimate the association between early-life use of treated nets and survival to adulthood. All the children born between January 1, 1998, and August 30, 2000, in the study area were invited to enroll in a longitudinal study from 1998 through 2003. Adult survival outcomes were verified in 2019 through community outreach and mobile telephones. We used Cox proportional-hazards models to estimate the association between the use of treated nets in early childhood and survival to adulthood, adjusting for potential confounders.ResultsA total of 6706 children were enrolled. In 2019, we verified information on the vital status of 5983 participants (89%). According to reports of early-life community outreach visits, approximately one quarter of children never slept under a treated net, one half slept under a treated net some of the time, and the remaining quarter always slept under a treated net. Participants who were reported to have used treated nets at half the early-life visits or more had a hazard ratio for death of 0.57 (95% confidence interval [CI], 0.45 to 0.72) as compared with those who were reported to have used treated nets at less than half the visits. The corresponding hazard ratio between 5 years of age and adulthood was 0.93 (95% CI, 0.58 to 1.49).ConclusionsIn this long-term study of early-life malaria control in a high-transmission setting, the survival benefit from early-life use of treated nets persisted to adulthood. (Funded by the Eckenstein-Geigy Professorship and others.).Copyright © 2022 Massachusetts Medical Society.

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