• Internal medicine · Sep 2022

    Case Reports

    Collagenous Colitis Possibly Associated with Dipeptidyl Peptidase-4 Inhibitor: Report of a Case.

    • Hironobu Takedomi, Yasuhisa Sakata, Michito Tomonaga, Naomi Naruse, Takahiro Yukimoto, Takashi Akutagawa, Nanae Tsuruoka, Ryo Shimoda, Shinichi Kido, and Motohiro Esaki.
    • Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan.
    • Intern. Med. 2022 Sep 15; 61 (18): 2731-2734.

    AbstractA 60-year-old man with type 2 diabetes mellitus treated with a dipeptidyl peptidase-4 (DPP-4) inhibitor was referred to our hospital because of his refractory watery diarrhea. Ileocolonoscopy revealed increased capillary growth, fine granular mucosa, and longitudinal mucosal tears mainly in the left side of the colon. A bioptic examination revealed thickened subepithelial collagen bands, thus confirming the diagnosis of collagenous colitis. Systemic steroid therapy was initiated, but his symptoms recurred when tapering the steroid. However, withdrawal of the DPP-4 inhibitor was successful even after the cessation of steroid therapy. We therefore considered his collagenous colitis to have been caused by the DPP-4 inhibitor.

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