• Chayakrit Krittanawong, Neil Sagar Maitra, Hassan VirkHafeez UlHUHarrington Heart & Vascular Institute, Case Western Reserve University, University Hospitals Cleveland Medical Center, Ohio., Sonya Fogg, Zhen Wang, Scott Kaplin, David Gritsch, Eric A Storch, Philippe N Tobler, Dennis S Charney, and Glenn N Levine.
• Section of Cardiology, Baylor College of Medicine, Houston, Texas. Electronic address: Chayakrit.Krittanawong@va.gov.
• Am. J. Med. 2022 Jul 1; 135 (7): 856863.e2856-863.e2.

BackgroundThe effect of psychological health on cardiovascular disease is an underappreciated yet important area of study. Understanding the relationship between these two entities may allow for more comprehensive care of those with cardiovascular disease. The primary objective of this meta-analysis is to evaluate the relationship between optimism and risk of developing adverse events such as all-cause mortality or fatal and non-fatal cardiovascular disease in community-based populations.MethodA systematic search of electronic databases was conducted from inception through November 2021 for prospective studies evaluating optimism and adverse outcomes. Two reviewers independently selected prospective cohort studies that evaluated optimism and either all-cause mortality or cardiovascular disease and reported hazard ratios of these outcomes between optimistic and non-optimistic groups. Studies that reported odds ratio or other risk assessments were excluded. Pooled hazard ratios were calculated in random-effects meta-analyses.ResultsPooled analysis of six studies (n = 181,709) showed a pooled hazard ratio of 0.87 (95% confidence interval [CI], 0.82-0.92) for all-cause mortality among those with more optimistic mindset. Analysis of seven studies (n = 201,210) showed a pooled hazard ratio of 0.59 (95% CI, 0.37-0.93) for cardiovascular disease and pooled hazard ratio of 0.57 (95% CI, 0.07-4.56) for stroke.ConclusionsIn this pooled meta-analysis, optimism was associated with a reduced risk of all-cause mortality and of cardiovascular disease. These results suggest an important relationship between psychological health and cardiovascular disease that may serve as an area for intervention by clinicians.Copyright © 2022 Elsevier Inc. All rights reserved.

9 keywords...

hide…