• Guojian He, Xiucai Zhang, Ting Yan, Jiayi Wang, Qi Li, Tianyu Liu, and Youn-Poong Oh.
• Physical Education Department, Hebei University of Economics and Business, Shijiazhuang, Hebei, China.
• Medicine (Baltimore). 2022 Feb 4; 101 (5): e28330e28330.

BackgroundDepression is a commonly occurring and recurrent mental disorder cross the world. Tai Chi is a traditional Chinese mind-body exercise which could be used to treat mental disorders including depression. This study aimed to conduct a systematic review and meta-analysis to assess the efficiency of Tai Chi for patients with depression.MethodsThis protocol follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol statement. Literature will be searched at PubMed, EMBASE, Web of Science, Cochrane Library, China Biology Medicine Database, China National Knowledge Infrastructure, Technology Journal Database, and Wan Fang database from the start date to September 2021. The Review Manager 5.3 software will be used to manage literature. After literature screening, 2 reviewers will extract data from the respects of general information, methodology, and results. The data analysis will be conducted with Review Manager and Stata 16 software, and the publication bias and literature quality will be both evaluated.ResultsThe results will contain the evaluation of clinical efficacy of Tai Chi practice for depression, as well as the assessment of literature quality and publication bias.ConclusionThe current review will provide new evidence on whether and to what extent patients with depression can benefit from Tai Chi practice.Registration number: DOI: 10.17605/OSF.IO/AUDNQ (https://osf.io/audnq).Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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