• Hung-Chuan Yu, Wang-Da Liu, Po-Hsien Kuo, Chien-Chin Lin, and Un-In Wu.
• Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
• Medicine (Baltimore). 2022 Feb 4; 101 (5): e28721e28721.

RationaleCytomegalovirus (CMV) disease is relatively uncommon in nontransplant hematological patients. Moreover, cutaneous manifestations of CMV diseases have scarcely been reported and are probably under-recognized.Patient ConcernsWe describe a patient with large B-cell lymphoma who developed a band-form, erythematous lesion over his left abdomen soon after the second course of rituximab, cyclophosphamide, doxorubicin, vincristine, prednisolone chemotherapy.DiagnosesThe lesion was initially mistaken for bacterial cellulitis or herpes zoster and was histologically confirmed as cutaneous CMV infection. Subsequent work-up also detected CMV viremia and the presence of CMV meningoencephalitis.InterventionsThe patient was treated with ganciclovir plus CMV immune globulin followed by foscarnet.OutcomesAlthough the patient's cutaneous lesion resolved, his cognitive impairment did not recover, and he developed a fatal multi-organ failure 1 month later.LessonsCutaneous CMV disease can herald multisystem involvement and an unfavorable prognosis in immunocompromised hosts. It should be ruled out with biopsy in patients with hematological malignancy who have cutaneous lesions refractory to antibacterial therapy.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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