• Gianluca Coppola, Delphine Magis, Francesco Casillo, Gabriele Sebastianelli, Chiara Abagnale, Ettore Cioffi, Davide Di Lenola, Cherubino Di Lorenzo, and Mariano Serrao.
• Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino, Latina, Italy. gianluca.coppola@uniroma1.it.
• Curr Pain Headache Rep. 2022 Mar 1; 26 (3): 267-278.

Purpose Of ReviewWe reviewed the literature that explored the use of central and peripheral neuromodulation techniques for chronic daily headache (CDH) treatment.Recent FindingsAlthough the more invasive deep brain stimulation (DBS) is effective in chronic cluster headache (CCH), it should be reserved for extremely difficult-to-treat patients. Percutaneous occipital nerve stimulation has shown similar efficacy to DBS and is less risky in both CCH and chronic migraine (CM). Non-invasive transcutaneous vagus nerve stimulation is a promising add-on treatment for CCH but not for CM. Transcutaneous external trigeminal nerve stimulation may be effective in treating CM; however, it has not yet been tested for cluster headache. Transcranial magnetic and electric stimulations have promising preventive effects against CM and CCH. Although the precise mode of action of non-invasive neuromodulation techniques remains largely unknown and there is a paucity of controlled trials, they should be preferred to more invasive techniques for treating CDH.© 2022. The Author(s).

18 keywords...

hide…