• Xiao Li, Xiuhuan Wang, Yu Wang, Xiaoyun Liu, Xueyang Ren, Ying Dong, Jiamu Ma, Ruolan Song, Jing Wei, Axiang Yu, Qiqi Fan, Jianling Yao, Dongjie Shan, Yanfei Zhang, Shengli Wei, and Gaimei She.
• School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, P. R. China.
• Am. J. Chin. Med. 2022 Jan 1; 50 (2): 471-509.

AbstractDendrobium polysaccharides (DPSs) have aroused people's increasing attention in recent years as a result of their outstanding edible and medicinal values and non-toxic property. This review systematically summarized recent progress in the different preparation techniques, structural characteristics, modification, various pharmacological activities and molecular mechanisms, structure-activity relationships, and current industrial applications in the medicinal, food, and cosmetics fields of DPSs. Additionally, some recommendations for future investigations were provided. A variety of methods were applied for the extraction and purification of DPSs. They possessed primary structures (e.g., glucomannan, rhamnogalacturonan I type pectin, heteroxylan, and galactoglucan) and conformational structures (e.g., random coil, rod, globular, and a slight triple-helical). And different molecular weights, monosaccharide compositions, linkage types, and modifications could largely affect DPSs' bioactivities (e.g., immunomodulatory, anti-diabetic, hepatoprotective, gastrointestinal protective, antitumor, anti-inflammatory, and anti-oxidant activities). It was worth mentioning that DPSs were significant pharmaceutical remedies and therapeutic supplements especially due to their strong immunity enhancement abilities. We hope that this review will lay a solid foundation for further development and applications of Dendrobium polysaccharides.

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