• Jun Chen, Xingxin Wang, Kai Wang, Zhihao Liu, Xiaoya Lv, Ming Wang, and Shoudan Sun.
• Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
• Medicine (Baltimore). 2022 Feb 11; 101 (6): e28731e28731.

BackgroundRecurrent aphthous stomatitis (RAS), are common inflammatory lesions of the oral mucous, usually round or ovoid, circumscribed by erythematous haloes with a yellow-grey floor and mostly painful. The purpose of this study was to evaluate the efficacy and safety of fire needle in the treatment of RAS.MethodsPubMed, EMBASE, the Cochrane Library, Chinese National Knowledge Infrastructure, Chinese VIP Information, Wanfang Database, and Chinese Biomedical Literature Database were searched by 2 reviewers from the inception until December 2021. The original study that randomized control trials of fire needle for RAS will be selected and is not limited by country or language. In addition, researches in progress, the reference lists and the citation lists of identified publications will be retrieved similarly. Study selection, data extraction, and assessment of the quality will be performed independently by 2 reviewers who have been trained prior to data extraction. A meta-analysis will be conducted if the quantity and quality of the original studies included are satisfactory; otherwise, a descriptive analysis will be conducted. Review Manager V5.4 software will be using for data synthesis and assessment of the risk of bias according to Cochrane Handbook.ResultsThis study will provide a comprehensive review of current evidence for the treatment of fire needle on RAS.ConclusionThe conclusion of this study will provide a judging basis that whether the treatment of RAS with fire needle is effective.Inplasy Registration NumberINPLASY2021120118.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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