• Yuan-Ling Chang and Shin-Tsu Chang.
• Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
• Medicine (Baltimore). 2022 Feb 11; 101 (6): e28758e28758.

RationaleSleep disturbance is commonly noted after Guillain-Barré syndrome (GBS) and is often caused by persistent discomfort after disease survival. Intravascular laser irradiation of blood (ILIB) has been shown to be effective in pain modulation owing to the influence of nociceptive signals in the peripheral nervous system. We investigated the application of ILIB on post-Oxford -AstraZeneca vaccination GBS and evaluated its effect on sleep quality.Patient ConcernsA 48-year-old woman was subsequently diagnosed with GBS after Oxford-AstraZeneca vaccination. The patient was discharged after a 5-day course of intravenous immunoglobulin administration. However, 1 week after discharge, the previously relieved symptoms flared with accompanying sleep disturbance.Diagnosis And InterventionsThe patient was diagnosed with post-vaccination GBS, and persistent pain and sleep disturbances persisted after disease survival. ILIB was performed.OutcomesWe used the Pittsburgh Sleep Quality Index before and after intravascular laser irradiation. There was a marked improvement in the sleep duration, efficiency, and overall sleep quality. The initial score was 12 out of 21 and the final score was 7 out of 21.LessonsWe found that ILIB was effective in pain modulation in post-vaccination GBS and significantly improved sleep quality.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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