• Kai Huang.
• Department of Spinal Orthopaedics, The Second People's Hospital of Changshu, Changshu, China.
• Medicine (Baltimore). 2022 Feb 11; 101 (6): e28761e28761.

BackgroundBone metastasis (BM) has become an important health problem. In recent years, studies on BM are growing rapidly, but there were no bibliometric studies regarding BM. This study aimed to illustrate the overall knowledge structure and development trends of BM.MethodsResearch datasets were acquired from the Web of Science database. The time span was defined as "1980-2020". VOS viewer and Citespace software was provided to analyze the data and generate visualization knowledge maps. Annual trends of publications, distribution, H-index status, co-authorship status, and research hotspots were analyzed.ResultsSix hundred eighty-two publications met the requirement. USA published most papers (264, 38.7%), and both total citations (13,997) and H-index (57) of USA ranked first. The most productive institution on BM is Amgen Inc. (43). Supportive Care in Cancer (24) published the most papers on BM. "Safety", "skeletal related event", "open label", "management", "health", and "prognosis" are the research hotspots in the recent years.ConclusionIn this study, we conduct a systematic and comprehensive analysis on the research in BM field. The publication number was rising in recent years stably. USA contributed mostly not only in quality, but also in quantity. Amgen Inc. published the largest number of articles, Supportive Care in Cancer was the most productive journal related to BM. "Safety", "skeletal related event", "open label", "management", "health", and "prognosis" are the research hotspots in recent years. We believe this study can not only show the global research overview in past 40 years but also point the research trend of BM in the future.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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