• Jun Ho Choi, Hyun Myung Oh, Kwang Seog Kim, Yoo Duk Choi, Sung Pil Joo, Won Joo Hwang, Jae Ha Hwang, and Sam Yong Lee.
• Department of Plastic and Reconstructive Surgery, Chonnam National University Medical School, Chonnam National University Hospital, Gwangju, Republic of Korea.
• Medicine (Baltimore). 2022 Feb 11; 101 (6): e28808e28808.

RationaleApocrine carcinoma is a rare malignant sweat gland tumor that has been reported in approximately 200 cases. This tumor usually occurs in the axilla, but in rare cases, it can also develop in the scalp. In the present work, we report 2 cases of cutaneous apocrine carcinoma of the scalp.Patient ConcernsTwo men visited our outpatient clinic with recurrence of tumor after undergoing surgery for scalp tumor at another hospital.DiagnosesBrain magnetic resonance imaging of a 56-year old man showed the presence of a 5.0 × 4.5 × 4.4 cm scalp mass in the right parietal region, invading the skull and dura mater and a 2.2 × 2.0 × 0.7 cm bony mass without any skin lesions right next to the scalp mass. Neck magnetic resonance imaging of a 76-year-old man revealed the presence of a well-defined oval mass in the subcutaneous layer of the left occipital scalp and 2 enlarged lymph nodes in the left neck. Definite diagnoses were made postoperatively. The patients were diagnosed with cutaneous apocrine carcinoma. The diagnosis was confirmed through histopathological and immunohistochemical staining tests.InterventionsThe tumors were removed with a wide safety margin and reconstructive surgery was performed.OutcomesAdditional radiotherapy or chemotherapy was performed. Follow-up more than 6 months revealed no recurrence or metastasis.LessonsIf accurate diagnosis and treatment had taken place at the initial stages of the primary cutaneous apocrine carcinoma, it would have been possible to prevent recurrence and intracranial invasion. As recurrent primary cutaneous apocrine carcinoma can become aggressive and difficult to treat, even a small mass on the scalp must be evaluated carefully and treated properly.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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