• Pain Med · Aug 2022

    Pain Burden in the CASiRe International Cohort of Sickle Cell Patients: United States and Ghana.

    • William T Zempsky, Mary Yanaros, Mohammed Sayeem, Donna Boruchov, Connie M Piccone, Deepa Manwani, Crawford Strunk, Immacolata Tartaglione, Raffaella Colombatti, Sophia Akatue, Bianca Oteng, Ahmed Owda, Rose Bamfo, Samuel Wilson, Angela Rivers, Fatimah Farooq, Rebekah Urbonya, Gifty Dankwah Boatemaa, Sudha Rao, Baba Inusa, Charles Antwi-Boasiako, Catherine Segbefia, Fredericka Sey, Biree Andemariam, Eugenia Vicky Asare, and Andrew D Campbell.
    • Department of Pediatrics, University of Connecticut School of Medicine, Connecticut Children's Medical Center, Hartford, Connecticut, USA.
    • Pain Med. 2022 Aug 1; 23 (8): 1379-1386.

    ObjectivesSickle Cell Disease (SCD) is a genetic blood disorder affecting over 1 million people globally. The aim of this analysis is to explore the pain burden of patients with SCD in two countries: the United States and Ghana.MethodsThe Consortium for the Advancement of Sickle Cell Research (CASiRe) was created to better understand the clinical severity of patients with SCD worldwide. Data regarding gender, SCD genotype, prior medical diagnoses, and validated pain burden measures were analyzed from the CASiRe database. The Sickle Cell Pain Burden Interview (SCPBI) was used to assess pain burden, the impact of pain on physical, emotional, and social function.ResultsMost subjects identified as Black/African American (n = 298, 97.0%). Patient ages ranged from 6 to 73 years. 35.9% resided in the United States, 64.1% resided in Ghana, 40.9% were men, and 58.7% were women. The mean SCPBI score for US SCD patients was 6.53(±5.89) vs 4.04(±5.10) for Ghanaian patients, P <0.001. Pain burden was higher in US men vs Ghanaian men (6.74(±5.68) vs 3.54(±4.46), P = .003) and in US women vs Ghanaian women (6.37 ± 6.06 vs 4.44(±5.54), P = .032). Pain burden was higher in US patients than Ghanaian patients for both the Hb SC/SBeta+ genotype (5.40(±5.29) vs 2.82(±4.86), P = .054) and Hb SS/SBeta0 genotype (6.79(±6.01) vs 4.49(±5.13), P = .003). Pain burden was significantly higher in SCD patients with comorbid conditions independent of geographic origin including stroke, cholecystectomy, gallstones, depression, and headache.DiscussionUS patients with SCD have a higher pain burden than Ghanaian patients. Further studies should investigate underlying contributors to pain burden in these populations and further explore the etiology of geographic differences in pain.© The Author(s) 2022. Published by Oxford University Press on behalf of the American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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