• Emily L Pierce, Alexandra A Mandel, Jeffrey A Strelzik, Raquel L Langdon, William M McClintock, Mark W Cameron, Emily E McCracken, and Marc T DiSabella.
• Department of Neurology, Children's National Hospital, Washington, DC, USA.
• Pain Med. 2022 Aug 31; 23 (9): 1536-1543.

ObjectiveThe objective of this study is to document pain scores during withdrawal of abortive medication in patients diagnosed with medication overuse headache.DesignCross-sectional study.SettingChildren's National Hospital's Headache Program.SubjectsPatients 6-18 years of age who presented to the Headache Clinic at Children's National Hospital with presumed medication overuse headache between March 2017 and March 2019 were invited to participate.MethodsPatients were instructed to abruptly discontinue overused medications and record their headache characteristics daily in a diary for 8 weeks.ResultsFourteen diaries were returned and analyzed at a 4-week follow-up visit. Ninety-three percent of the patients were females, with a median age of 14.9 years (standard deviation [SD] = 2.0). The average headache intensity upon study entry was 4.7 out of 10 (SD = 2.5), and the average headache intensity upon study completion was 3.1 (SD = 2.5). Of the patients, 57% had daily headaches upon study entry, 71% had improved pain intensity from the first diary entry to the last diary entry, and 57% had complete headache resolution at an average of 7.6 days from medication discontinuation (SD = 5.1). Ibuprofen was the most overused medication (71%).ConclusionsOur findings suggest that medication overuse headache will improve in the majority of pediatric patients who abruptly stop the offending medication(s) in an average of 8 days from withdrawal. Average pain intensity was reduced by more than one point among all patients who stopped taking abortive medications. Further larger-scale studies on medication withdrawal in pediatric patients with medication overuse headache could help us better understand whether this management strategy is effective.© The Author(s) 2022. Published by Oxford University Press on behalf of the American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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