• J. Cardiothorac. Vasc. Anesth. · Aug 2022

    Electrocardiographic Features and Outcome: Correlations in 124 Hospitalized Patients With COVID-19 and Cardiovascular Events.

    • Pavani Nathala, Vidyulata Salunkhe, Harideep Samanapally, Qian Xu, Stephen Furmanek, Omar H Fahmy, Fnu Deepti, Alex Glynn, Trevor McGuffin, Dylan C Goldsmith, Jessica Petrey, Tshura Ali, Derek Titus, Ruth Carrico, Julio Ramirez, Demetra Antimisiaris, Sean P Clifford, Siddharth Pahwa, Lynn Roser, Maiying Kong, Jiapeng Huang, and Center of Excellence for Research in Infectious Diseases (CERID) Coronavirus Study Group on behalf of the COVID-19 Cardiovascular Research Group (COVID-CVRG).
    • Division of Infectious Diseases, Center of Excellence for Research in Infectious Diseases, University of Louisville, Louisville, KY.
    • J. Cardiothorac. Vasc. Anesth. 2022 Aug 1; 36 (8 Pt B): 292729342927-2934.

    ObjectivesElectrocardiographic (ECG) changes have been associated with coronavirus disease 2019 (COVID-19) severity. However, the progression of ECG findings in patients with COVID-19 has not been studied. The purpose of this study was to describe ECG features at different stages of COVID-19 cardiovascular (CV) events and to examine the effects of specific ECG parameters and cardiac-related biomarkers on clinical outcomes in COVID-19.DesignRetrospective, cohort study.SettingMajor tertiary-care medical centers and community hospitals in Louisville, KY.ParticipantsA total of 124 patients with COVID-19 and CV events during hospitalization.InterventionsNone.Measurements And Main ResultsTwelve-lead ECG parameters, biomarkers of cardiac injuries, and clinical outcomes were analyzed with Spearman correlation coefficients and Kruskal-Wallis 1-way analysis of variance. Atrial fibrillation/atrial flutter was more frequent on the ECG obtained at the time of the CV event when compared with admission ECG (9.5% v 26.9%; p = 0.007). Sinus tachycardia was higher in the last available hospital ECG than the CV event ECG (37.5% v 20.4%; p = 0.031). Admission ECG-corrected QT interval was significantly associated with admission troponin levels (R = 0.52; p < 0.001). The last available hospital ECG showed nonsurvivors had longer QRS duration than survivors (114.6 v 91.2 ms; p = 0.026), and higher heart rate was associated with longer intensive care unit length of stay (Spearman ρ = 0.339; p = 0.032).ConclusionsIn hospitalized patients with COVID-19 and CV events, ECGs at various stages of COVID-19 hospitalization showed significantly different features with dissimilar clinical outcome correlations.Copyright © 2022 Elsevier Inc. All rights reserved.

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