• Kanako Katayama, Toru Arai, Takehiko Kobayashi, Sayoko Shintani, Naoko Takeuchi, Yoshinobu Matsuda, Chikatoshi Sugimoto, Yasushi Inoue, Maiko Takeda, Takahiko Kasai, Masanori Akira, and Yoshikazu Inoue.
• Department of Internal Medicine, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan.
• Intern. Med. 2022 Jan 1; 61 (4): 533-540.

AbstractAirway-centered fibroelastosis is a distinct entity characterized by prominent airway-centered elastosis of the upper lobe with little or no pleural involvement. Little is known regarding its etiology; however, it was reported to have an idiopathic or asthma-associated etiology. We document, for the first time, 2 women (19 and 60 years old) who developed pleuroparenchymal fibroelastosis with a predominantly airway-centered distribution as a late complication (6 and 9 years later, respectively) of chemotherapy. The disease rapidly progressed following the manifestation of symptoms, and they subsequently died (3 and 2 years later, respectively). Therefore, post-chemotherapy long-term monitoring for this disease is warranted.

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