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- A Lescoat, S Jouneau, Y Uzunhan, P Jégo, V Cottin, and E Hachulla.
- Inserm, EHESP, Irset (institut de recherche en santé, environnement et travail), UMR_S 1085, université Rennes, CHU de Rennes, Rennes, France; Department of Internal Medicine and Clinical Immunology, Rennes University Hospital, Rennes, France. Electronic address: alain.lescoat@chu-rennes.fr.
- Rev Med Interne. 2022 Jun 1; 43 (6): 365-374.
AbstractSystemic sclerosis (SSc) is an autoimmune disease associated to fibrotic manifestations. Interstitial lung disease (SSc-ILD), one of the main fibrotic features of SSc, is the first cause of SSc-related death. The management of SSc-ILD has recently benefited from the results of key randomised controlled trials. French authorities have approved Nintedanib for the treatment of SSc-ILD, and tocilizumab has recently been approved by the Food and Drug Administration (FDA) in the United-States (US). These recent approvals challenge the management of this fibrotic manifestation of SSc. This narrative literature review, at the crossroad of internal medicine and pulmonology, discusses what could be an up-to date approach, in terms of diagnostic and therapeutic strategies for SSc-ILD, in the light of the results from recent clinical trials.Copyright © 2021. Published by Elsevier Masson SAS.
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