• Dirk J Bosch, Gertrude J Nieuwenhuijs-Moeke, Matijs van Meurs, Wayel H Abdulahad, and StruysMichel M R FMMRFDepartment of Anesthesiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Basic and Applied Medical Sciences, Ghent University, Ghent, Belgium..
• Department of Anesthesiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
• Anesthesiology. 2022 May 1; 136 (5): 843-860.

AbstractNonsteroidal anti-inflammatory drugs are among the most commonly administered drugs in the perioperative period due to their prominent role in pain management. However, they potentially have perioperative consequences due to immune-modulating effects through the inhibition of prostanoid synthesis, thereby affecting the levels of various cytokines. These effects may have a direct impact on the postoperative outcome of patients since the immune system aims to restore homeostasis and plays an indispensable role in regeneration and repair. By affecting the immune response, consequences can be expected on various organ systems. This narrative review aims to highlight these potential immune system-related consequences, which include systemic inflammatory response syndrome, acute respiratory distress syndrome, immediate and persistent postoperative pain, effects on oncological and neurologic outcome, and wound, anastomotic, and bone healing.Copyright © 2022, the American Society of Anesthesiologists. All Rights Reserved.

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