• Lancet · Apr 1994

    Case Reports

    Insulin independence in a type 1 diabetic patient after encapsulated islet transplantation.

    • P Soon-Shiong, R E Heintz, N Merideth, Q X Yao, Z Yao, T Zheng, M Murphy, M K Moloney, M Schmehl, and M Harris.
    • St Vincent Medical Center, Los Angeles, CA 90057.
    • Lancet. 1994 Apr 16; 343 (8903): 950951950-1.

    AbstractIdentification of a biocompatible immunoprotective membrane to prevent graft rejection remained elusive until the development of microcapsules formulated in alginate high in guluronic acid. We report insulin independence in a type 1 diabetic patient after encapsulated islet transplantation. Encapsulated human islets were injected intraperitoneally in a diabetic patient with a functioning kidney graft. Insulin independence with tight glycaemic control was demonstrated 9 months after the procedure. These results warrant a trial of a high dose of encapsulated islets in early-onset diabetic patients.

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