• Andrzej Dzik-Jurasz, Claudia Domenig, Mark George, Jan Wolber, Anwar Padhani, Gina Brown, and Simon Doran.
• UK Cancer Research Clinical Magnetic Resonance Research Group, Institute of Cancer Research, Royal Marsden NHS Trust, Downs Road, Sutton SM2 5PT, UK. andrzej@icr.ac.uk
• Lancet. 2002 Jul 27; 360 (9329): 307-8.

AbstractPrediction of tumour response before onset of treatment could have considerable clinical benefit. Since the apparent diffusion coefficient (ADC) of a tumour's water content can show the extent of necrosis, we looked for a possible correlation of ADC with response to treatment. We measured mean tumour water ADC before and after chemotherapy and chemoradiation in 14 patients with locally advanced rectal cancer, with a quantitative magnetic resonance diffusion imaging sequence. We found a strong negative correlation between mean pretreatment tumour water ADC and percentage size change of tumours after chemotherapy (r=-0.67, p=0.01) and chemoradiation (r=-0.83, p=0.001). Persistence of low ADC in responders after chemotherapy could represent loss of a non-viable fraction of the treated tumour.

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