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- S Fourmond, B Gutierrez, M P Gourin, S Delaumenie, and K H Ly.
- Service de dermatologie, CHU de Limoges, 16, rue Bernard-Descottes, 87042 Limoges, France. Electronic address: salome.fourmond@chu-limoges.fr.
- Rev Med Interne. 2022 May 1; 43 (5): 312-315.
IntroductionApremilast is a phosphodiesterase 4 inhibitor used in psoriasis and psoriatic arthritis Recently, this treatment has received marketing authorization for severe and refractory oral aphthosis in Behçet's disease. Idiopathic recurrent aphthous stomatitis (RAS) outside of Behçet's disease is often difficult to treat and can affect patients' quality of life.Case ReportsWe report our experience with the use of apremilast in two 49-year-old patients with refractory oral aphthosis not related to Behçet's disease or another etiology. In both cases, a combination of apremilast with low-dose prednisone controlled the idiopathic RAS within a few weeks.ConclusionApremilast, which already has marketing authorization for Behçet's disease, also appears to be effective in RAS.Copyright © 2022 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.
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