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- Kazuhiro Itoh, Yasuhiko Mitsuke, Mami Wakahara, Tatsuya Yoshioka, Nozomi Otsuki, Yusuke Suzuki, Chiyo Kiriba, Atsushi Kuwata, Ippei Sakamaki, Hiromichi Iwasaki, and Hiroshi Tsutani.
- Department of Internal Medicine, National Hospital Organization Awara Hospital, Japan.
- Intern. Med. 2022 Sep 15; 61 (18): 2809-2811.
AbstractAmenamevir has been approved for the treatment of herpes zoster (HZ); however, its therapeutic efficacy against central nervous system (CNS) infection may be insufficient due to its low spinal fluid permeability. We herein report a case of aseptic meningitis in a 91-year-old Japanese man treated with amenamevir for HZ in the trigeminal nerve region. Several cases of CNS infection have been reported in patients receiving amenamevir treatment for HZ. Patients with CNS complications often have skin rashes near the trigeminal region. Thus, we should be alert for signs of CNS infection when administering amenamevir to patients with such rashes.
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