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- Kenichi Kishimoto, Kotaro Shibagaki, Saya Nonomura, Shohei Sumi, Naoki Fukuda, Yusuke Takahashi, Satoshi Kotani, Eiko Okimoto, Naoki Oshima, Kousaku Kawashima, Norihisa Ishimura, and Shunji Ishihara.
- Department of Gastroenterology, Faculty of Medicine, Shimane University, Japan.
- Intern. Med. 2022 Sep 15; 61 (18): 2735-2740.
AbstractHeterotopic gastric mucosa (HGM) of esophagus, primarily occurring in cervical esophagus, is usually asymptomatic. A healthy woman (mid-40s) with postprandial heartburn was diagnosed with middle esophageal HGM and esophageal ulcers by esophagogastroduodenoscopy. Using 8-channel pH monitoring, a sensor near the HGM area detected postprandial acid phase (pH 3-4), while areas adjacent to the proximal and distal sensors were neutral, suggesting acid secretion from the HGM. A biopsy showed fundic gland tissue expressing H+/K+-ATPase and pepsinogen-I. Oral vonoprazan improved the clinical symptoms and endoscopic findings. This is the first report using 8-channel pH monitoring to diagnose extremely rare middle esophageal HGM.
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