• Internal medicine · Sep 2022

    Case Reports

    A Case of Graves' Disease with Thymic Hyperplasia: The Response of the Thyroid Function, Thyrotropin Receptor Autoantibody, and Thymic Size to Thiamazole Treatment.

    • Daichi Tsukada, Katsumi Iizuka, Ken Takao, Yanyan Liu, Sodai Kubota, Saki Okamoto-Kubota, Teruaki Sakurai, Toshinori Imaizumi, Mayu Sakai, Takehiro Kato, Masami Mizuno, Takuo Hirota, Tetsuya Suwa, Yukio Horikawa, Mayumi Yamamoto, Sumihisa Kubota, and Daisuke Yabe.
    • Department of Diabetes, Endocrinology and Metabolism/Department of Rheumatology and Clinical Immunology, Gifu University Graduate School of Medicine, Japan.
    • Intern. Med. 2022 Sep 15; 61 (18): 2753-2757.

    AbstractWe treated a 22-year-old woman suffering from Graves' disease and thymic hyperplasia. She was referred to our institution for a close investigation of thyrotoxicosis and thymic mass. Thyroid tests and magnetic resonance imaging resulted in a diagnosis of Graves' disease and thymic hyperplasia. The thyroid function and thyroid-stimulating hormone receptor antibody (TRAb) were normalized one and five months after thiamazole initiation, respectively. The thymic size began to decrease after 1 month and was further decreased after 5 months; it was normalized after 12 months. The correlation between TRAb titers and the thymic size (R2=0.99) suggested that the patient's autoimmunity might have contributed to the thymic hyperplasia.

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