• Internal medicine · Sep 2022

    Case Reports

    Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia Incidentally Detected by Fluorodeoxyglucose-positron Emission Tomography/Computed Tomography at a Health Checkup.

    • Hisako Kunieda, Ryunosuke Denda, Kohei Yamazaki, Maki Hirao, Yuiko Tsukada, Yu Iwabuchi, Eisuke Shiomi, Shigeru Watanabe, Shinichiro Okamoto, and Takahide Kikuchi.
    • Department of Hematology, Saiseikai Central Hospital, Japan.
    • Intern. Med. 2022 Sep 15; 61 (18): 2775-2778.

    AbstractWe herein report a case of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph-ALL) that was incidentally detected by fluorodeoxyglucose-positron emission tomography (18F-FDG PET)/computed tomography (CT) at a health checkup. At that time, the findings of a physical examination and blood tests were all normal, except for the diffuse bone marrow uptake (maximum standardized uptake value: 6.3). One month later, when the blood counts remained in the normal ranges, a bone marrow examination confirmed the diagnosis of Ph-ALL. Although a diffuse bone marrow uptake of 18F-FDG is observed in some benign conditions, physicians should also consider the possibility of hematological malignancies, including acute leukemia, even when that is the only abnormal finding.

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