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- Takahiro Natori, Toko Fukao, Tsubasa Watanabe, Takafumi Kurita, Takanori Hata, Akio Kimura, Kazumasa Shindo, Takayoshi Shimohata, and Yoshihisa Takiyama.
- Department of Neurology, University of Yamanashi Hospital, Japan.
- Intern. Med. 2022 Oct 1; 61 (19): 2947-2950.
AbstractWe herein report a 47-year-old man with autoimmune glial fibrillary acidic protein astrocytopathy (GFAP-A) revealed by periventricular radial linear enhancement on repeated brain magnetic resonance imaging (MRI). He presented with a history of headache and a fever followed by somnolence and worsening of consciousness. On admission (16 days from the onset), although lymphocytic pleocytosis and hypoglycorrhachia in the cerebrospinal fluid (CSF) were noted, initial brain MRI demonstrated non-specific findings. At 30 days from the onset, repeated brain MRI revealed characteristic findings of GFAP-A, and we detected anti-GFAP antibodies in the CSF. Thus, repeated brain MRI provides clues for the diagnosis of GFAP-A.
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