• Internal medicine · Jan 2022

    Case Reports

    Syndrome of Inappropriate Antidiuretic Hormone Secretion as the Initial Presentation in a Patient with Stage I Small-cell Lung Cancer.

    • Tomonobu Koizumi, Takashi Kobayashi, Shintaro Kanda, Toshirou Fukushima, Futoshi Muranaka, Kentaro Miura, and Shiho Asaka.
    • Department of Hematology and Medical Oncology, Shinshu University School of Medicine, Japan.
    • Intern. Med. 2022 Jan 1; 61 (5): 709-713.

    AbstractA 67-year-old man with a history of esophageal cancer resection was referred to our hospital because of nausea and appetite loss. Laboratory findings showed severe hyponatremia and were compatible with syndrome of inappropriate antidiuretic hormone (SIADH) secretion. Chest computed tomography (CT) revealed a nodule measuring 13 mm in the lower lobe of the right lung. Right thoracotomy was performed, and the histopathological diagnosis was small-cell lung cancer (T1bN0M0; Stage 1b). Although SIADH is frequently associated with small-cell lung cancer, it is extremely rare as the initial clinical feature in stage I small-cell lung cancer.

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