• J. Investig. Med. · Aug 2022

    Telomere length in patients with alcohol-associated liver disease: a brief report.

    • Nazmul Huda, Praveen Kusumanchi, Kristina Perez, Yanchao Jiang, Nicholas J Skill, Zhaoli Sun, Jing Ma, Zhihong Yang, and Suthat Liangpunsakul.
    • Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
    • J. Investig. Med. 2022 Aug 1; 70 (6): 143814411438-1441.

    AbstractThe intact telomere structure is essential for the prevention of the chromosome end-to-end fusions and maintaining genomic integrity. The maintenance of telomere length is critical for cellular homeostasis. The shortening of telomeres has been reported in patients with chronic liver diseases. The telomere length has not been systemically studied in patients with alcohol-associated liver disease (ALD) at different stages, such as alcoholic hepatitis and alcoholic cirrhosis. In this brief report, we observed evidence of telomere shortening without changes in the telomerase activity in the liver of patients with alcoholic hepatitis and alcoholic cirrhosis when compared with controls. The alterations in the genes associated with telomere binding proteins were only observed in patients with alcoholic cirrhosis. Future studies are required to determine the mechanism of how alcohol affects the length of the telomere and if the shortening impacts the disease progression in ALD.© American Federation for Medical Research 2022. No commercial re-use. See rights and permissions. Published by BMJ.

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