• Mujun Wang, Wei Liu, Wenxing Liu, and Chao Wang.
• The First People's Hospital of Jinan City, Department of Surgery - Jinan, China.
• Rev Assoc Med Bras (1992). 2022 Feb 1; 68 (2): 170-175.

ObjectiveA growing volume of literature has suggested long noncoding RNAs (lncRNAs) as important players in tumor progression. In this study, we aimed to investigate the expression and prognostic value of lncRNA LINC00173 (LINC00173) in melanoma.MethodsLINC00173 expression was measured in 163 paired cancerous and noncancerous specimen samples by real-time polymerase chain reaction. The correlations between LINC00173 expression with clinicopathological characteristics and prognosis were analyzed by chi-square test, log-rank test, and multivariate survival analysis. Receiver-operating characteristic curves were used for the assessment of the diagnostic value of LINC00173 for melanoma patients.ResultsThe expression level of LINC00173 in melanoma specimens was distinctly higher than that in adjacent non-neoplasm specimens (p<0.01). Besides, LINC00173 was expressed more frequently in patients with advanced melanoma than in patients with early melanoma. Multivariate assays confirmed that LINC00173 expression level was an independent prognostic predictor of melanoma patients (p<0.05).ConclusionOur data indicated that LINC00173 expression could serve as an unfavorable prognostic biomarker for melanoma patients.

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