• Fang Wang, Hongcheng Zhu, Xiaoju Yang, and Fang Liao.
• Department of Obstetrics and Gynaecology, The National Hospital Of Enshi Autonomous Prefecture, Enshi, Hubei Province, China.
• Medicine (Baltimore). 2022 Mar 4; 101 (9): e28964e28964.

BackgroundPostpartum depression is one of the most common complications during the postpartum period. In recent years, internet-based psychological interventions have made significant progress and provided a new psychotherapy model. Internet-based cognitive behavioral therapy (ICBT) for postpartum depression has achieved good results. However, the effectiveness of ICBT for postpartum depression reported by different studies still remains inconsistent. Therefore, a meta-analysis was used to further evaluate the efficacy of ICBT for postpartum depression, aiming to provide evidence to support nonpharmacological intervention strategies in the clinic.MethodsThe databases of PubMed, Web of Science, Scopus, Cochrane Library, Embase, China Scientific Journal Database, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, and Wanfang Data will be searched. The randomized controlled trials of ICBT will be included for postpartum depression published before February 2022. Two independent researchers will independently complete literature selection, risk of bias assessment and data extraction. The disagreements will be discussed with a third party for the final decision. Cochrane Risk of Bias Assessment Tool will be used for literature quality assessment. Data processing will be conducted by RevMan 5.4 software.ResultsThe results of this meta-analysis will be submitted to a peer-reviewed journal for publication.ConclusionsFor the question whether ICBT for postpartum depression is efficacy, this study can provide more comprehensive and strong evidence.Ethics And DisseminationThe ethical approval was not required for this study. The systematic review will be published in a peer-reviewed journal, presented at conferences, and shared on social media platforms.Osf Registration NumberDOI 10.17605/OSF.IO/EQJDH.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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