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- Ryo Yanagiya, Masahiro Wanezaki, Naohisa Nakamura, Tsubasa Ichikawa, Tatsuya Hayasaka, Akane Yamada, Keiko Aizawa, Satoshi Ito, Masahito Himuro, Hiroto Suzuki, Masakazu Yamamoto, Tomomi Toubai, Masafumi Watanabe, and Kenichi Ishizawa.
- Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology (3rd Department of Internal Medicine), Faculty of Medicine, Yamagata University, Japan.
- Intern. Med. 2022 Sep 15; 61 (18): 2779-2784.
AbstractCardiotoxicity is a critical complication of allogeneic hematopoietic cell transplantation (allo-HCT). In particular, management of severe cardiotoxicity occurring in the early phases of allo-HCT is challenging. We encountered a case of severe cardiotoxicity resulting from AHF six days after allo-HCT, which resisted catecholamines and diuretics. The patient was treated with anthracycline-containing regimens and underwent myeloablative conditioning, including high-dose cyclophosphamide. As invasive circulatory assisting devices were contraindicated because of his immunocompromised status and bleeding tendency, we successfully treated the patient with ivabradine-containing medications. Ivabradine may therefore be considered an alternative drug for the treatment of severe cardiotoxicity induced by cytotoxic agents.
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